21700 battery offers several advantages over the 18650 battery and can replace it in some situations. However, due to differences in size and weight, 21700 battery cannot completely replace 18650. Smaller electronic devices may still be better suited for the 18650 battery.

Capacity
21700 lithium battery typically has capacity ranging from 3000mAh to 5000mAh, while the 18650 battery ranges from 1200mAh to 3600mAh. As result, 21700 battery generally provides longer runtime and higher energy output in the same volume or weight.
Energy Density and Runtime
21700 battery features higher energy density and single-cell capacity. Within the same volume, it delivers longer runtime and a longer lifespan. Its lower internal resistance also improves charge/discharge efficiency and reduces heat generation, contributing to longer service life. Additionally, its larger size allows for thicker electrolytes and separators, enhancing safety.
Although the 18650 battery has smaller capacity, it still performs well in compact devices where space is limited, making it good choice for certain applications.
Discharge Performance
The larger size of the 21700 battery enables it to handle higher discharge currents, making it suitable for devices that require high current output, such as power tools and electric bikes. While the 18650 battery cannot match the 21700 in this regard, it still delivers sufficient performance for most everyday electronics.
Cost and Price
21700 battery usually costs more due to higher production costs and greater material usage. In contrast, the 18650 battery benefits from large-scale production and mature technology, offering a more affordable and cost-effective solution.

Safety
In terms of safety, the 21700 and 18650 batteries are quite similar. Both require proper handling and maintenance to avoid overheating, short circuits, and other safety hazards.
Applications
21700 battery, with its high capacity and high current discharge capability, suits high-power applications such as power tools, electric bikes, drones, and energy storage systems. The 18650 battery, on the other hand, is more suitable for devices with size constraints, such as laptops, flashlights, instruments, audio equipment, RC models, toys, camcorders, digital cameras, and other compact electronics.
Conclusion
Both 21700 and 18650 lithium batteries have their own advantages and ideal use cases. The best choice depends on your specific needs and budget. Regardless of which battery you choose, proper usage and charging are essential to ensure safety and optimal performance.